HPF1

Across TCGA cell cohorts, HPF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,465 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HPF1-associated GO terms across cancer lineages are Regulation of protein ADP-ribosylation, Regulation of chromosome separation, and Nuclear division. Each is linked with HPF1 in more than 16 cancer types. Because this analysis shows association rather than direction, both HPF1-to-partner and partner-to-HPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein ADP-ribosylation grouped by HPF1-low versus HPF1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPF1→partner) and Y-score (partner→HPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of protein ADP-ribosylation →	+0.188	+1.361	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome separation →	+0.141	+0.964	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Nuclear division →	+0.081	+0.820	.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.175	+1.108	<.001	<.001	3	16
STOMACH	Metaphase chromosome alignment →	+0.114	+1.010	<.001	<.001	3	15
LUNG_NSCLC_LUSC	DNA damage tolerance →	+0.080	+1.175	.006	.002	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,465 associations by consensus.

Regulation of protein ADP-ribosylation by HPF1 expression — URINARY_TRACT

Explore this box plot interactively →