Across TCGA patient cohorts, HPDL RNA expression is significantly associated with the protein abundance of many other proteins, with 18,609 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HPDL-associated proteins across cancer lineages are PARP1, MSH6, and RPRD2. Each is linked with HPDL in more than 6 cancer types. Because this analysis shows association rather than direction, both HPDL-to-partner and partner-to-HPDL results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPDL→partner) and Y-score (partner→HPDL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PARP1 →	+0.443	+0.445	<.001	<.001	3	7
LSCC	MSH6 →	+0.504	+0.691	<.001	<.001	3	7
OV	RPRD2 →	+0.344	+1.057	<.001	.001	3	7
GBM	SMARCA5 →	+0.368	+0.477	<.001	<.001	3	7
LSCC	CEBPZ →	+0.354	+1.010	<.001	<.001	3	7
LSCC	MTPAP →	+0.419	+0.922	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,609 associations by consensus.

Exploration

HPDL survival (RNA) · tumor vs normal (RNA) · all HPDL data types