Across TCGA patient cohorts, HPDL mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPDL-associated genes across cancer lineages are EGFR_pY1068, Ku80, and Notch1. Each is linked with HPDL in more than 1 cancer types. Because this analysis shows association rather than direction, both HPDL-to-partner and partner-to-HPDL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPDL→partner) and Y-score (partner→HPDL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.343	-3.459	.006	.005	3	1
UCEC	Ku80 →	+0.336	+2.820	.004	.035	3	1
UCEC	Notch1 →	+0.265	+2.321	<.001	.035	3	1
UCEC	Rab25 →	-0.378	-2.321	.023	.035	3	1
UCEC	Annexin-1 →	+0.909	+3.189	<.001	.010	3	1
UCEC	Shc_pY317 →	-0.257	-2.321	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

HPDL survival (RNA) · tumor vs normal (RNA) · all HPDL data types