HPD

Across TCGA patient cohorts, HPD mutation is significantly associated with the RNA expression of many other genes, with 2,127 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPD-associated genes across cancer lineages are ZNHIT3, UHRF1, and RPS3AP33. Each is linked with HPD in more than 1 cancer types. Because this analysis shows association rather than direction, both HPD-to-partner and partner-to-HPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNHIT3 grouped by HPD-low versus HPD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPD→partner) and Y-score (partner→HPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNHIT3 →	+0.483	+2.413	<.001	<.001	3	2
UCEC	UHRF1 →	+0.951	+2.885	<.001	<.001	3	2
BRCA	RPS3AP33 →	+0.104	+4.566	<.001	.005	3	2
SKCM	SNRPD3 →	+0.440	+3.341	.006	.005	3	2
UCEC	PSMA3 →	+0.325	+2.914	.008	.001	3	2
UCEC	SRP54 →	+0.497	+2.042	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,127 associations by consensus.

ZNHIT3 by HPD expression — UCEC

Explore this box plot interactively →