HPD

Across TCGA patient cohorts, HPD mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPD-associated genes across cancer lineages are PCNA, Bak, and C-Raf. Each is linked with HPD in more than 1 cancer types. Because this analysis shows association rather than direction, both HPD-to-partner and partner-to-HPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by HPD-low versus HPD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPD→partner) and Y-score (partner→HPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.192	+2.999	.027	.035	3	2
UCEC	Bak →	+0.229	+1.906	.023	.016	3	2
UCEC	C-Raf →	+0.192	+3.321	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.111	-3.432	.006	.005	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.631	+2.415	.001	.003	3	1
UCEC	MSH2 →	-0.296	-3.295	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PCNA by HPD expression — UCEC

Explore this box plot interactively →