HPD

Across TCGA cell cohorts, HPD RNA expression is significantly associated with the go_rna of many other GO terms, with 1,459 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible HPD-associated GO terms across cancer lineages are Positive regulation of striated muscle contraction, Phospholipase C-activating G protein-coupled receptor signaling pathway, and mRNA transport. Each is linked with HPD in more than 6 cancer types. Because this analysis shows association rather than direction, both HPD-to-partner and partner-to-HPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of striated muscle contraction grouped by HPD-low versus HPD-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPD→partner) and Y-score (partner→HPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of striated muscle contraction →	-0.255	-0.130	.001	.006	3	7
UPPER_AERODIGESTIVE_TRACT	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-0.056	-0.221	<.001	.001	3	6
URINARY_TRACT	mRNA transport →	+0.063	+0.119	<.001	.005	3	5
URINARY_TRACT	Establishment of RNA localization →	+0.072	+0.161	<.001	.007	3	5
URINARY_TRACT	RNA export from nucleus →	+0.063	+0.122	<.001	.003	3	5
OESOPHAGUS	mRNA cis splicing, via spliceosome →	+0.089	+0.305	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,459 associations by consensus.

Positive regulation of striated muscle contraction by HPD expression — URINARY_TRACT

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