HPCAL4

Across TCGA patient cohorts, HPCAL4 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPCAL4-associated genes across cancer lineages are HER3, CDK1_pY15, and S6_pS240_S244. Each is linked with HPCAL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPCAL4-to-partner and partner-to-HPCAL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by HPCAL4-low versus HPCAL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCAL4→partner) and Y-score (partner→HPCAL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	-0.283	-2.990	.049	.036	3	1
UCEC	CDK1_pY15 →	+0.229	+2.829	.045	.035	2	1
UCEC	S6_pS240_S244 →	+0.510	+3.321	.016	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

HER3 by HPCAL4 expression — UCEC

Explore this box plot interactively →