HPCAL4

Across TCGA cell cohorts, HPCAL4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HPCAL4-associated genes across cancer lineages are MAGEB4, STRA8, and ZNF804B. Each is linked with HPCAL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPCAL4-to-partner and partner-to-HPCAL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by HPCAL4-low versus HPCAL4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCAL4→partner) and Y-score (partner→HPCAL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ZNF804B →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DBX2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.336	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAGEB4 by HPCAL4 expression — LARGE_INTESTINE

Explore this box plot interactively →