HPCAL1

Across TCGA pan-cancer cohorts, HPCAL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HPCAL1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HPCAL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HPCAL1 expression acts as an unfavorable survival marker.

CCRCC, LSCC, and PDAC are the cancer types where HPCAL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.552	0.889	<.001	39	view →
LSCC	OS	Quartile	All	0.586	0.941	<.001	26	view →
PDAC	DFS	Quartile	All	0.689	0.918	.005	24	view →
LUAD	OS	Quartile	III,IV	0.258	0.918	.013	16	view →
UCEC	OS	Quartile	All	0.803	1.000	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HPCAL1–CCRCC (DFS)

Open the CCRCC breakdown →