HPCAL1

Across TCGA patient cohorts, HPCAL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,033 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPCAL1-associated proteins across cancer lineages are SPCS3, CTSL, and SPCS1. Each is linked with HPCAL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HPCAL1-to-partner and partner-to-HPCAL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPCAL1 versus SPCS3 in CCRCC, with a Pearson correlation of -0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCAL1→partner) and Y-score (partner→HPCAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SPCS3 →	-0.535	-0.808	<.001	<.001	3	4
GBM	CTSL →	+0.375	+0.510	<.001	<.001	3	4
CCRCC	SPCS1 →	-0.461	-0.622	<.001	.002	3	3
CCRCC	SPCS2 →	-0.463	-0.629	.004	.001	3	3
CCRCC	CD38 →	-0.648	-0.531	.006	.005	2	4
CCRCC	DDAH1 →	+0.532	+0.655	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,033 associations by consensus.

HPCAL1 vs SPCS3 — CCRCC

Explore this scatter interactively →