HPCAL1

Across TCGA patient cohorts, HPCAL1 mutation is significantly associated with the RNA expression of many other genes, with 332 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPCAL1-associated genes across cancer lineages are RNA5SP281, MIR550A2, and SNORD116-15. Each is linked with HPCAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HPCAL1-to-partner and partner-to-HPCAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP281 grouped by HPCAL1-low versus HPCAL1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCAL1→partner) and Y-score (partner→HPCAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP281 →	+0.281	+4.625	<.001	.008	3	3
SKCM	MIR550A2 →	+0.366	+3.501	.001	.005	3	2
COAD	SNORD116-15 →	+0.705	+4.283	<.001	.001	3	2
COAD	GPC6-AS2 →	+0.206	+3.736	.004	.005	3	2
UCEC	KRTAP23-1 →	+0.205	+2.547	.005	.009	3	2
UCEC	RN7SKP204 →	+0.263	+2.813	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 332 associations by consensus.

RNA5SP281 by HPCAL1 expression — LUSC

Explore this box plot interactively →