HPCAL1

Across TCGA patient cohorts, HPCAL1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPCAL1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, AMPK_pT172, and VEGFR2. Each is linked with HPCAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPCAL1-to-partner and partner-to-HPCAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by HPCAL1-low versus HPCAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCAL1→partner) and Y-score (partner→HPCAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.608	+3.009	.029	.019	3	1
UCEC	AMPK_pT172 →	+0.447	+3.183	.047	.010	3	1
UCEC	VEGFR2 →	+0.343	+3.183	.035	.010	2	1
UCEC	ERK2 →	+0.234	+3.169	.026	.020	1	1
UCEC	p62 Lck ligand →	+0.415	+3.169	.020	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Acetyl-a-Tubulin-Lys40 by HPCAL1 expression — UCEC

Explore this box plot interactively →