HPCAL1

Across TCGA cell cohorts, HPCAL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,373 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HPCAL1-associated GO terms across cancer lineages are PML body organization, Positive regulation of focal adhesion assembly, and Regulation of plasminogen activation. Each is linked with HPCAL1 in more than 13 cancer types. Because this analysis shows association rather than direction, both HPCAL1-to-partner and partner-to-HPCAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML body organization grouped by HPCAL1-low versus HPCAL1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPCAL1→partner) and Y-score (partner→HPCAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PML body organization →	+0.216	+1.914	<.001	<.001	3	14
BONE	Positive regulation of focal adhesion assembly →	+0.268	+1.878	<.001	<.001	3	14
LIVER	Regulation of plasminogen activation →	+0.323	+1.431	.001	.006	3	13
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.191	+2.079	<.001	<.001	3	13
BONE	Actin filament depolymerization →	+0.203	+1.770	<.001	<.001	3	13
LIVER	Urokinase plasminogen activator signaling pathway →	+1.161	+1.710	.003	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,373 associations by consensus.

PML body organization by HPCAL1 expression — BONE

Explore this box plot interactively →