HP1BP3

Across TCGA pan-cancer cohorts, HP1BP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HP1BP3 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HP1BP3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HP1BP3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where HP1BP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.453	0.763	<.001	51	view →
LUAD	OS	Median	III,IV	0.218	0.616	.023	15	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	14	view →
PDAC	DFS	Tertile	III,IV	0.753	0.219	.017	9	view →
LSCC	DFS	Median	All	0.894	0.518	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HP1BP3–HNSC (DFS)

Open the HNSC breakdown →