HP1BP3

Across TCGA pan-cancer cohorts, HP1BP3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HP1BP3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where HP1BP3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HP1BP3 is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

LUAD, PDAC, and COAD are the cancer types where HP1BP3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HP1BP3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.692	<.001	9	view →
PDAC	Female	II,III,IV	−0.394	<.001	9	view →
COAD	Female	II,III,IV	−0.254	<.001	9	view →
LSCC	Male	II,III,IV	−0.535	<.001	8	view →
CCRCC	Male	All	+0.214	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HP1BP3–LUAD

Open the LUAD breakdown →