HP1BP3

Across TCGA patient cohorts, HP1BP3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HP1BP3-associated genes across cancer lineages are eIF4E, ASNS, and ATM. Each is linked with HP1BP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HP1BP3-to-partner and partner-to-HP1BP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HP1BP3-low versus HP1BP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HP1BP3→partner) and Y-score (partner→HP1BP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.211	+2.807	.005	<.001	3	2
UCEC	ASNS →	+0.518	+1.906	<.001	.015	3	2
UCEC	ATM →	-0.420	-2.321	.010	.005	3	2
UCEC	14-3-3_beta →	-0.081	-1.847	.024	.049	3	1
UCEC	eEF2 →	+0.354	+2.459	.006	.018	3	1
UCEC	EGFR_pY1068 →	-0.296	-1.925	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eIF4E by HP1BP3 expression — UCEC

Explore this box plot interactively →