HP1BP3

Across TCGA cell cohorts, HP1BP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,626 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HP1BP3-associated GO terms across cancer lineages are Microtubule cytoskeleton organization involved in mitosis, Positive regulation of organelle assembly, and Centrosome duplication. Each is linked with HP1BP3 in more than 17 cancer types. Because this analysis shows association rather than direction, both HP1BP3-to-partner and partner-to-HP1BP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule cytoskeleton organization involved in mitosis grouped by HP1BP3-low versus HP1BP3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HP1BP3→partner) and Y-score (partner→HP1BP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Microtubule cytoskeleton organization involved in mitosis →	+0.083	+0.729	.001	<.001	3	18
LUNG_NSCLC_LUSC	Positive regulation of organelle assembly →	+0.079	+1.217	<.001	.001	3	17
LUNG_SCLC	Centrosome duplication →	+0.096	+0.812	<.001	<.001	3	16
BLOOD_Lymphoma	Positive regulation of chromosome organization →	+0.074	+0.971	<.001	<.001	3	16
LUNG_SCLC	Regulation of microtubule-based process →	+0.055	+0.714	.002	.001	3	16
SOFT_TISSUE	Cell division →	+0.078	+1.168	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,626 associations by consensus.

Microtubule cytoskeleton organization involved in mitosis by HP1BP3 expression — BONE

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