HP1BP3

Across TCGA cell cohorts, HP1BP3 mutation is significantly associated with the RNA expression of many other genes, with 166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HP1BP3-associated genes across cancer lineages are PDE6H, RNF133, and GSG1L2. Each is linked with HP1BP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HP1BP3-to-partner and partner-to-HP1BP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE6H grouped by HP1BP3-low versus HP1BP3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HP1BP3→partner) and Y-score (partner→HP1BP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PDE6H →	+0.102	+3.951	.001	.005	3	1
BLOOD_Leukemia	RNF133 →	+0.057	+3.705	<.001	.007	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
SKIN	HELT →	+0.060	+4.095	<.001	.009	3	1
LARGE_INTESTINE	MTFMT →	+0.587	+3.212	.002	.006	3	1
LARGE_INTESTINE	C1QBP →	+0.745	+3.299	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 166 associations by consensus.

PDE6H by HP1BP3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →