HP

Across TCGA pan-cancer cohorts, HP mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HP data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HP expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where HP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.595	0.868	.002	42	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	32	view →
UCEC	OS	Median	III,IV	0.449	1.000	.010	28	view →
COAD	DFS	Median	IV	0.565	1.000	.028	18	view →
GBM	DFS	Tertile	All	0.589	0.858	.001	11	view →
LSCC	OS	Median	All	0.916	1.000	.007	3	view →
PDAC	OS	Tertile	II,III,IV	0.667	0.953	.028	3	view →
HNSC	OS	Tertile	IV	0.896	0.652	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HP–CCRCC (OS)

Open the CCRCC breakdown →