HP

Across TCGA patient cohorts, HP RNA expression is significantly associated with the protein abundance of many other proteins, with 15,716 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HP-associated proteins across cancer lineages are NELFA, NNMT, and CRYBG3. Each is linked with HP in more than 4 cancer types. Because this analysis shows association rather than direction, both HP-to-partner and partner-to-HP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HP versus NELFA in GBM, with a Pearson correlation of -0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HP→partner) and Y-score (partner→HP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NELFA →	-0.290	-1.470	<.001	.001	3	5
GBM	NNMT →	+0.881	+1.106	<.001	<.001	3	5
OV	CRYBG3 →	+0.302	+1.767	.002	.003	3	5
OV	SIAE →	+0.511	+1.379	<.001	.005	3	5
GBM	HMGB1 →	-0.422	-1.677	<.001	<.001	3	4
LSCC	PRPF4 →	-0.339	-1.659	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,716 associations by consensus.

HP vs NELFA — GBM

Explore this scatter interactively →