HP

Across TCGA patient cohorts, HP protein abundance is significantly associated with the RNA expression of many other genes, with 9,474 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HP-associated genes across cancer lineages are LYVE1, CR1, and F13A1. Each is linked with HP in more than 6 cancer types. Because this analysis shows association rather than direction, both HP-to-partner and partner-to-HP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HP versus LYVE1 in COAD, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HP→partner) and Y-score (partner→HP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LYVE1 →	+1.262	+0.850	<.001	<.001	3	7
GBM	CR1 →	+0.945	+0.651	<.001	<.001	3	7
GBM	F13A1 →	+1.381	+0.510	<.001	<.001	3	6
GBM	CD93 →	+0.794	+0.566	.003	.002	3	6
BRCA	HIF1A →	+0.698	+0.685	.005	<.001	3	5
COAD	MEDAG →	+1.477	+0.853	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,474 associations by consensus.

HP vs LYVE1 — COAD

Explore this scatter interactively →