HP

Across TCGA patient cohorts, HP mutation is significantly associated with the RNA expression of many other genes, with 1,325 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HP-associated genes across cancer lineages are NDUFA12, C19orf54, and LONP1. Each is linked with HP in more than 1 cancer types. Because this analysis shows association rather than direction, both HP-to-partner and partner-to-HP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA12 grouped by HP-low versus HP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HP→partner) and Y-score (partner→HP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA12 →	+0.346	+3.721	<.001	<.001	3	2
UCEC	C19orf54 →	+0.346	+2.263	.002	.005	3	2
UCEC	LONP1 →	+0.624	+2.403	<.001	<.001	3	2
UCEC	PRIM1 →	+0.560	+1.695	.004	.007	3	2
UCEC	AKT1S1 →	+0.298	+2.032	.003	.001	3	2
UCEC	TRAJ57 →	+0.415	+2.231	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,325 associations by consensus.

NDUFA12 by HP expression — UCEC

Explore this box plot interactively →