HP

Across TCGA patient cohorts, HP mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HP-associated genes across cancer lineages are Myosin-IIa_pS1943, Myosin-IIa, and Notch1. Each is linked with HP in more than 1 cancer types. Because this analysis shows association rather than direction, both HP-to-partner and partner-to-HP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by HP-low versus HP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HP→partner) and Y-score (partner→HP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.214	+2.515	.008	.001	3	1
UCEC	Myosin-IIa →	+0.171	+1.914	.021	.009	3	1
UCEC	Notch1 →	+0.153	+1.584	.005	.036	3	1
UCEC	p62 Lck ligand →	+0.323	+3.321	.011	.009	3	1
UCEC	PCNA →	+0.175	+1.584	.039	.036	3	1
UCEC	Annexin-1 →	+0.602	+2.584	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Myosin-IIa_pS1943 by HP expression — UCEC

Explore this box plot interactively →