HP

Across TCGA cell cohorts, HP RNA expression is significantly associated with the go_rna of many other GO terms, with 1,229 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HP-associated GO terms across cancer lineages are Protein demannosylation, Protein alpha-1,2-demannosylation, and Induction of bacterial agglutination. Each is linked with HP in more than 3 cancer types. Because this analysis shows association rather than direction, both HP-to-partner and partner-to-HP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein demannosylation grouped by HP-low versus HP-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HP→partner) and Y-score (partner→HP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Protein demannosylation →	+0.072	+0.282	.001	.009	3	4
CNS	Protein alpha-1,2-demannosylation →	+0.072	+0.282	.001	.009	3	4
BLOOD_Leukemia	Induction of bacterial agglutination →	+1.083	+1.223	<.001	<.001	3	4
SOFT_TISSUE	Alcohol biosynthetic process →	+0.066	+0.590	<.001	.001	3	3
SOFT_TISSUE	Positive regulation of wound healing →	-0.091	-0.340	.002	.007	3	3
BONE	Positive regulation of the force of heart contraction →	-0.642	-0.477	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,229 associations by consensus.

Protein demannosylation by HP expression — CNS

Explore this box plot interactively →