HOXD4

Across TCGA patient cohorts, HOXD4 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,990 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HOXD4-associated proteins across cancer lineages are SRPX, TLN1_S1641, and TLN2. Each is linked with HOXD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both HOXD4-to-partner and partner-to-HOXD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD4 versus SRPX in UCEC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD4→partner) and Y-score (partner→HOXD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SRPX →	+0.604	+0.743	<.001	<.001	3	4
UCEC	TLN1_S1641 →	+1.086	+0.995	<.001	<.001	3	4
BRCA	TLN2 →	+0.444	+0.800	.001	.006	3	4
UCEC	VCL →	+0.438	+0.831	<.001	<.001	3	4
BRCA	ZEB1 →	+0.556	+1.039	<.001	<.001	3	4
BRCA	CAVIN3 →	+0.628	+0.804	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,990 associations by consensus.

HOXD4 vs SRPX — UCEC

Explore this scatter interactively →