HOXD4

Across TCGA patient cohorts, HOXD4 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD4-associated genes across cancer lineages are 4E-BP1, eIF4E, and INPP4B. Each is linked with HOXD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD4-to-partner and partner-to-HOXD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by HOXD4-low versus HOXD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD4→partner) and Y-score (partner→HOXD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.273	+2.029	.010	.017	3	2
UCEC	eIF4E →	+0.186	+2.700	.024	.006	3	1
UCEC	INPP4B →	-0.252	-2.000	.047	.029	3	1
UCEC	p62 Lck ligand →	+0.364	+2.000	.004	.010	3	1
UCEC	PCNA →	+0.288	+2.000	<.001	.010	3	1
UCEC	Rab11 →	-0.123	-2.321	.030	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

4E-BP1 by HOXD4 expression — UCEC

Explore this box plot interactively →