HOXD4

Across TCGA cell cohorts, HOXD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,741 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOXD4-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Heterochromatin formation, and Negative regulation of myoblast fusion. Each is linked with HOXD4 in more than 7 cancer types. Because this analysis shows association rather than direction, both HOXD4-to-partner and partner-to-HOXD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by HOXD4-low versus HOXD4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD4→partner) and Y-score (partner→HOXD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.091	+0.446	<.001	.006	3	8
STOMACH	Heterochromatin formation →	+0.059	+0.593	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.096	+0.475	<.001	.003	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.048	+0.493	.005	.002	2	8
CNS	Protein deneddylation →	+0.059	+0.456	<.001	.007	3	7
BONE	Purine nucleoside triphosphate metabolic process →	+0.066	+1.283	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,741 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by HOXD4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →