HOXD4

Across TCGA cell cohorts, HOXD4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HOXD4-associated genes across cancer lineages are APCS, BSND, and OR10G7. Each is linked with HOXD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD4-to-partner and partner-to-HOXD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APCS grouped by HOXD4-low versus HOXD4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD4→partner) and Y-score (partner→HOXD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	APCS →	+0.136	+3.643	.002	.007	3	1
CNS	BSND →	+0.042	+4.201	<.001	.003	3	1
CNS	OR10G7 →	+0.008	+4.772	<.001	.002	3	1
CNS	MUC22 →	+0.028	+4.193	<.001	.007	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

APCS by HOXD4 expression — CNS

Explore this box plot interactively →