HOXD3

Across TCGA patient cohorts, HOXD3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,577 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HOXD3-associated proteins across cancer lineages are PFKM_S775, PLVAP, and PPP1R12A. Each is linked with HOXD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both HOXD3-to-partner and partner-to-HOXD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD3 versus PFKM_S775 in PDAC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD3→partner) and Y-score (partner→HOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PFKM_S775 →	+1.238	+0.287	<.001	<.001	3	4
CCRCC	PLVAP →	+0.664	+0.497	<.001	<.001	3	4
UCEC	PPP1R12A →	+0.375	+0.734	<.001	<.001	3	4
GBM	PTPRC_S994 →	-0.828	-0.970	<.001	.003	3	4
CCRCC	THY1 →	+0.562	+0.522	<.001	<.001	3	4
UCEC	LMNA →	+0.561	+0.744	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,577 associations by consensus.

HOXD3 vs PFKM_S775 — PDAC

Explore this scatter interactively →