HOXD3

Across TCGA patient cohorts, HOXD3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,625 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HOXD3-associated genes across cancer lineages are SPN, GIMAP6, and TMEM106C. Each is linked with HOXD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXD3-to-partner and partner-to-HOXD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HOXD3 versus SPN in COAD, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD3→partner) and Y-score (partner→HOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SPN →	+1.292	+1.031	<.001	.001	3	3
OV	GIMAP6 →	+1.404	+1.959	<.001	<.001	3	2
COAD	TMEM106C →	-0.916	-0.987	.006	.006	3	2
OV	FGD2 →	+0.809	+1.327	.003	.004	3	2
LSCC	NLRC3 →	+1.572	+1.259	.005	.001	3	2
COAD	EMB →	+1.842	+0.663	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,625 associations by consensus.

HOXD3 vs SPN — COAD

Explore this scatter interactively →