HOXD3

Across TCGA patient cohorts, HOXD3 mutation is significantly associated with the RNA expression of many other genes, with 3,045 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD3-associated genes across cancer lineages are MRPS11, NOP10, and MCAT. Each is linked with HOXD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXD3-to-partner and partner-to-HOXD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS11 grouped by HOXD3-low versus HOXD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD3→partner) and Y-score (partner→HOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS11 →	+0.418	+2.464	<.001	<.001	3	3
UCEC	NOP10 →	+0.461	+4.130	<.001	<.001	3	3
UCEC	MCAT →	+0.391	+2.745	<.001	<.001	3	3
UCEC	USP14 →	+0.398	+2.272	.003	.001	3	3
UCEC	UQCRC1 →	+0.321	+2.431	.006	.001	3	3
UCEC	GPI →	+0.440	+2.069	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,045 associations by consensus.

MRPS11 by HOXD3 expression — UCEC

Explore this box plot interactively →