HOXD3

Across TCGA patient cohorts, HOXD3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD3-associated genes across cancer lineages are MEK1, PRAS40_pT246, and Rad50. Each is linked with HOXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD3-to-partner and partner-to-HOXD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by HOXD3-low versus HOXD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD3→partner) and Y-score (partner→HOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.471	+2.392	<.001	<.001	3	2
UCEC	PRAS40_pT246 →	+0.173	+2.115	.004	.017	3	2
UCEC	Rad50 →	-0.284	-2.209	<.001	.009	3	2
UCEC	ATM →	-0.375	-1.362	.019	.037	3	2
UCEC	eIF4E →	+0.220	+3.807	.003	<.001	2	2
UCEC	ERK2 →	+0.134	+1.700	.049	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by HOXD3 expression — UCEC

Explore this box plot interactively →