HOXD3

Across TCGA cell cohorts, HOXD3 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HOXD3-associated genes across cancer lineages are GSG1L2, KRTAP13-2, and ARMH2. Each is linked with HOXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD3-to-partner and partner-to-HOXD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by HOXD3-low versus HOXD3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD3→partner) and Y-score (partner→HOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	2
LUNG_NSCLC_LUSC	KRTAP13-2 →	+0.229	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ARMH2 →	+0.020	+4.643	<.001	.008	3	1
BLOOD_Leukemia	ASB10 →	+0.158	+4.551	<.001	.004	3	1
BLOOD_Leukemia	LMX1A →	+0.172	+4.409	<.001	.005	3	1
BLOOD_Leukemia	TMEM196 →	+0.053	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

GSG1L2 by HOXD3 expression — BLOOD_Leukemia

Explore this box plot interactively →