HOXD3

Across TCGA cell cohorts, HOXD3 mutation is significantly associated with the mutation status of many other genes, with 4,138 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXD3-associated genes across cancer lineages are ADAMTSL3, WNK1, and SNAP91. Each is linked with HOXD3 in more than 5 cancer types. Because this analysis shows association rather than direction, both HOXD3-to-partner and partner-to-HOXD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTSL3 grouped by HOXD3-low versus HOXD3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD3→partner) and Y-score (partner→HOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ADAMTSL3 →	+2.832	+3.601	.008	.008	1	6
LUNG_NSCLC_LUAD	WNK1 →	+3.078	+2.944	.003	.003	1	5
LUNG_NSCLC_LUAD	SNAP91 →	+3.662	+3.000	.007	.007	1	5
BLOOD_Leukemia	GLI2 →	+2.465	+4.629	<.001	<.001	1	5
BLOOD_Lymphoma	MYO1F →	+4.247	+4.554	.001	.001	1	5
BLOOD_Lymphoma	TRANK1 →	+2.832	+3.601	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

ADAMTSL3 by HOXD3 expression — BLOOD_Lymphoma

Explore this box plot interactively →