HOXD13

Across TCGA patient cohorts, HOXD13 mutation is significantly associated with the RNA expression of many other genes, with 2,092 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXD13-associated genes across cancer lineages are VCY, MIR1263, and C4orf3. Each is linked with HOXD13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD13-to-partner and partner-to-HOXD13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY grouped by HOXD13-low versus HOXD13-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD13→partner) and Y-score (partner→HOXD13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VCY →	+0.134	+8.471	<.001	.005	3	2
BRCA	MIR1263 →	+0.928	+8.471	<.001	.005	3	2
UCEC	C4orf3 →	+0.486	+2.695	.004	<.001	3	2
STAD	FABP5P4 →	+0.385	+4.031	.001	.005	3	2
STAD	RNU6-709P →	+0.577	+3.646	<.001	.009	3	2
COAD	RPL22P14 →	+0.215	+4.081	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,092 associations by consensus.

VCY by HOXD13 expression — BRCA

Explore this box plot interactively →