HOXD13

Across TCGA cell cohorts, HOXD13 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOXD13-associated genes across cancer lineages are TACR3, C10orf53, and DPPA5. Each is linked with HOXD13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD13-to-partner and partner-to-HOXD13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TACR3 grouped by HOXD13-low versus HOXD13-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD13→partner) and Y-score (partner→HOXD13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Lymphoma	C10orf53 →	+0.038	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	DPPA5 →	+0.208	+5.209	<.001	.005	3	1
BLOOD_Leukemia	SOX1 →	+0.624	+4.149	<.001	.008	1	1
BLOOD_Leukemia	SMIM32 →	+0.023	+4.169	.004	.008	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TACR3 by HOXD13 expression — BLOOD_Leukemia

Explore this box plot interactively →