HOXD12

Across TCGA patient cohorts, HOXD12 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible HOXD12-associated genes across cancer lineages are RNA5SP453, MIR4797, and H4C7. Each is linked with HOXD12 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXD12-to-partner and partner-to-HOXD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP453 grouped by HOXD12-low versus HOXD12-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD12→partner) and Y-score (partner→HOXD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP453 →	+0.219	+4.385	<.001	.008	3	3
LUSC	MIR4797 →	+0.505	+3.089	<.001	.001	3	2
LUSC	H4C7 →	+0.098	+2.861	.004	.006	3	2
SKCM	RN7SKP21 →	+0.183	+5.212	<.001	.002	3	2
SKCM	C1QBPP1 →	+0.057	+5.356	<.001	<.001	3	2
HNSC	LINC00850 →	+0.094	+5.241	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

RNA5SP453 by HOXD12 expression — SKCM

Explore this box plot interactively →