HOXD12

Across TCGA patient cohorts, HOXD12 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible HOXD12-associated genes across cancer lineages are p27_pT157, HER2, and p90 RSK. Each is linked with HOXD12 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD12-to-partner and partner-to-HOXD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by HOXD12-low versus HOXD12-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD12→partner) and Y-score (partner→HOXD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p27_pT157 →	+0.153	+2.834	.001	.035	2	1
LUSC	HER2 →	+0.774	+2.816	<.001	.036	1	1
LUSC	p90 RSK →	+0.199	+2.816	.042	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p27_pT157 by HOXD12 expression — LUSC

Explore this box plot interactively →