HOXD12

Across TCGA cell cohorts, HOXD12 mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXD12-associated genes across cancer lineages are OR8B8, SMIM23, and DMC1. Each is linked with HOXD12 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXD12-to-partner and partner-to-HOXD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B8 grouped by HOXD12-low versus HOXD12-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXD12→partner) and Y-score (partner→HOXD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR8B8 →	+0.062	+5.029	<.001	.006	3	1
BLOOD_Leukemia	SMIM23 →	+0.022	+5.569	<.001	.001	3	1
LARGE_INTESTINE	DMC1 →	+1.221	+3.212	<.001	.006	3	1
LARGE_INTESTINE	HFE →	+0.846	+3.212	.005	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.049	+3.465	.004	.002	3	1
LARGE_INTESTINE	TRIM37 →	+0.639	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

OR8B8 by HOXD12 expression — LUNG_SCLC

Explore this box plot interactively →