HOXC8

Across TCGA pan-cancer cohorts, HOXC8 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated HOXC8 data layer compared with 29 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher HOXC8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HOXC8 expression acts as an unfavorable survival marker.

SARC are the cancer types where HOXC8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.108	0.839	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

HOXC8–SARC (OS)

Open the SARC breakdown →