HOXC8

Across TCGA cell cohorts, HOXC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,966 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HOXC8-associated GO terms across cancer lineages are Positive regulation of multicellular organism growth, IMP salvage, and Regulation of heart contraction. Each is linked with HOXC8 in more than 8 cancer types. Because this analysis shows association rather than direction, both HOXC8-to-partner and partner-to-HOXC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of multicellular organism growth grouped by HOXC8-low versus HOXC8-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC8→partner) and Y-score (partner→HOXC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of multicellular organism growth →	-0.159	-1.171	.003	.002	3	9
SOFT_TISSUE	IMP salvage →	+0.164	+1.997	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of heart contraction →	-0.093	-0.929	.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of telomerase RNA localization to Cajal body →	+0.072	+0.782	.005	.006	3	8
URINARY_TRACT	tRNA transport →	+0.094	+1.022	.006	.001	3	8
LIVER	Translational initiation →	+0.073	+1.926	.005	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,966 associations by consensus.

Positive regulation of multicellular organism growth by HOXC8 expression — URINARY_TRACT

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