Across TCGA patient cohorts, HOXC4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,118 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HOXC4-associated genes across cancer lineages are SPRR3, MAFG-DT, and CCNY. Each is linked with HOXC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC4-to-partner and partner-to-HOXC4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC4→partner) and Y-score (partner→HOXC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SPRR3 →	-5.182	-0.612	.001	.007	3	2
BRCA	MAFG-DT →	+1.297	+1.482	.001	<.001	3	2
GBM	CCNY →	-0.576	-0.665	.003	.006	3	2
OV	SYTL1 →	-1.387	-1.505	.003	.001	3	2
UCEC	HOXC5 →	+0.539	+1.253	<.001	<.001	3	2
LSCC	RFLNA →	+1.193	+0.969	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,118 associations by consensus.

Exploration

HOXC4 survival (RNA) · tumor vs normal (RNA) · all HOXC4 data types