Across TCGA cell cohorts, HOXC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,514 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HOXC4-associated GO terms across cancer lineages are Positive regulation of intracellular estrogen receptor signaling pathway, Regulation of smoothened signaling pathway, and Regulation of pattern recognition receptor signaling pathway. Each is linked with HOXC4 in more than 6 cancer types. Because this analysis shows association rather than direction, both HOXC4-to-partner and partner-to-HOXC4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC4→partner) and Y-score (partner→HOXC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.145	+0.749	<.001	.001	3	7
SKIN	Regulation of smoothened signaling pathway →	+0.050	+1.313	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.075	+1.071	<.001	<.001	3	7
URINARY_TRACT	Regulation of cilium assembly →	+0.065	+1.603	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.073	+1.116	<.001	<.001	3	7
URINARY_TRACT	CAMP/PKA signal transduction →	+0.146	+1.251	.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,514 associations by consensus.

Exploration

HOXC4 survival (RNA) · tumor vs normal (RNA) · all HOXC4 data types