HOXC13

Across TCGA patient cohorts, HOXC13 mutation is significantly associated with the RNA expression of many other genes, with 2,925 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC13-associated genes across cancer lineages are MRPL32P1, MIR767, and RNU6-397P. Each is linked with HOXC13 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXC13-to-partner and partner-to-HOXC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL32P1 grouped by HOXC13-low versus HOXC13-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC13→partner) and Y-score (partner→HOXC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MRPL32P1 →	+0.195	+5.474	<.001	.005	3	3
STAD	MIR767 →	+0.301	+5.798	<.001	.003	3	2
LUSC	RNU6-397P →	+0.448	+7.327	<.001	<.001	3	2
CESC	MIR450A1 →	+0.618	+5.812	<.001	.003	3	2
HNSC	RNA5SP461 →	+0.247	+7.954	<.001	.008	3	2
LUAD	OR7K1P →	+0.054	+4.612	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,925 associations by consensus.

MRPL32P1 by HOXC13 expression — LUSC

Explore this box plot interactively →