HOXC13

Across TCGA patient cohorts, HOXC13 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC13-associated genes across cancer lineages are Notch1, ASNS, and ATM. Each is linked with HOXC13 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOXC13-to-partner and partner-to-HOXC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by HOXC13-low versus HOXC13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC13→partner) and Y-score (partner→HOXC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.181	+2.222	.002	.011	3	3
UCEC	ASNS →	+0.500	+2.459	.001	.019	3	2
UCEC	ATM →	-0.436	-1.700	.023	.044	3	2
UCEC	Caspase-8 →	-0.315	-3.673	.003	.001	3	2
UCEC	C-Raf →	+0.219	+2.906	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.330	-2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Notch1 by HOXC13 expression — UCEC

Explore this box plot interactively →