HOXC13

Across TCGA cell cohorts, HOXC13 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,904 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HOXC13-associated GO terms across cancer lineages are Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11), Spliceosomal snRNP assembly, and Regulation of RNA splicing. Each is linked with HOXC13 in more than 10 cancer types. Because this analysis shows association rather than direction, both HOXC13-to-partner and partner-to-HOXC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) grouped by HOXC13-low versus HOXC13-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC13→partner) and Y-score (partner→HOXC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) →	+0.133	+2.079	.001	<.001	3	11
LARGE_INTESTINE	Spliceosomal snRNP assembly →	+0.083	+1.404	<.001	<.001	3	11
OESOPHAGUS	Regulation of RNA splicing →	+0.087	+1.417	.005	.008	2	11
STOMACH	Regulation of mRNA splicing, via spliceosome →	+0.082	+2.032	.002	<.001	3	10
OESOPHAGUS	Regulation of mRNA processing →	+0.095	+1.625	.004	.006	2	11
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.152	+1.418	.004	.008	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,904 associations by consensus.

Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) by HOXC13 expression — BONE

Explore this box plot interactively →