HOXC13

Across TCGA cell cohorts, HOXC13 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HOXC13-associated genes across cancer lineages are OR2AJ1, RBMY1A1, and MRGPRE. Each is linked with HOXC13 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC13-to-partner and partner-to-HOXC13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by HOXC13-low versus HOXC13-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC13→partner) and Y-score (partner→HOXC13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	RBMY1A1 →	+0.015	+5.209	.008	.005	3	1
LARGE_INTESTINE	MRGPRE →	+0.062	+3.459	.003	.009	3	1
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SPRR1A →	+0.287	+5.201	<.001	.006	3	1
LUNG_SCLC	IFNA2 →	+0.019	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR2AJ1 by HOXC13 expression — BLOOD_Lymphoma

Explore this box plot interactively →