HOXC12

Across TCGA patient cohorts, HOXC12 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,444 significant associations in total. SARC shows the largest number of these associations.

The most reproducible HOXC12-associated GO terms across cancer lineages are Embryonic appendage morphogenesis, Positive regulation of cell cycle phase transition, and Positive regulation of mitotic cell cycle. Each is linked with HOXC12 in more than 14 cancer types. Because this analysis shows association rather than direction, both HOXC12-to-partner and partner-to-HOXC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Embryonic appendage morphogenesis grouped by HOXC12-low versus HOXC12-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC12→partner) and Y-score (partner→HOXC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	Embryonic appendage morphogenesis →	+0.031	+1.717	<.001	<.001	3	15
ACC	Positive regulation of cell cycle phase transition →	+0.040	+1.607	<.001	<.001	3	14
STAD	Positive regulation of mitotic cell cycle →	+0.038	+1.112	<.001	<.001	3	14
STAD	Nuclear membrane organization →	+0.040	+1.005	<.001	<.001	3	14
ACC	Microtubule cytoskeleton organization involved in mitosis →	+0.048	+1.592	<.001	<.001	3	13
STAD	Positive regulation of mitotic cell cycle phase transition →	+0.039	+1.077	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,444 associations by consensus.

Embryonic appendage morphogenesis by HOXC12 expression — SARC

Explore this box plot interactively →