HOXC12

Across TCGA patient cohorts, HOXC12 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible HOXC12-associated genes across cancer lineages are RNA5SP393, APOBEC3AP1, and CYLC1. Each is linked with HOXC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC12-to-partner and partner-to-HOXC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP393 grouped by HOXC12-low versus HOXC12-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC12→partner) and Y-score (partner→HOXC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP393 →	+0.554	+5.075	<.001	.001	3	2
STAD	APOBEC3AP1 →	+0.319	+4.646	<.001	.004	3	2
SKCM	CYLC1 →	+0.016	+5.469	<.001	.002	3	1
SKCM	RNU6-640P →	+0.530	+4.352	<.001	.007	3	1
SKCM	LINC00951 →	+0.172	+4.838	<.001	.002	3	1
SKCM	TRAJ42 →	+0.625	+4.410	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

RNA5SP393 by HOXC12 expression — SKCM

Explore this box plot interactively →