HOXC12

Across TCGA patient cohorts, HOXC12 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOXC12-associated genes across cancer lineages are MPP, Pericytes, and Osteoblast. Each is linked with HOXC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOXC12-to-partner and partner-to-HOXC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by HOXC12-low versus HOXC12-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOXC12→partner) and Y-score (partner→HOXC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MPP →	+0.011	+3.694	.008	.027	3	2
UCEC	Pericytes →	+0.039	+2.113	.015	.044	3	2
STAD	Osteoblast →	+0.022	+4.254	.037	.008	3	1
UCEC	B-cells →	+0.033	+3.158	.045	.004	3	1
UCEC	DC →	+0.037	+2.871	.003	.034	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MPP by HOXC12 expression — LUSC

Explore this box plot interactively →